CIMIT Forum: CO2-the Other Gas of Life: Effects on Sleep-respiration

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CO2-the Other Gas of Life: Effects on Sleep-respiration

4.27.2010

SPEAKER:
ROBERT J. THOMAS, MD MMSC, Director, Sleep Medicine Fellowship, Beth Israel Deaconess Medical Center; Assistant Professor in Medicine, Harvard Medical School; Visiting Scientist, Radiology (Martinos Center), Massachusetts General Hospital

MODERATOR:
J. WOODROW WEISS, MD, Associate Professor of Medicine, Harvard Medical School; Chief, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center; Member, Executive Committee, Harvard Medical School Division of Sleep Medicine

Video coming soon.

Forum Abstract

Oxygen and carbon dioxide regulation is critical for sustaining life. There is a large body of data describing the effect of hypoxia and hyperoxia on biological process, with less relatively known about CO2. In the area of sleep-disordered breathing, while it is known that hypocapnia and hypercapnia have profound effects on regulation of breathing (especially hypocapnia-associated central sleep apnea and periodic breathing), clinical translation has not occurred until now. The presentation will discuss the role of CO2 manipulation in the adjunctive treatment of chemoreflex-modulated sleep apnea, including an investigational device, the Positive Airway Pressure Gas Modulator (PAPGAM) and dead space adapted to positive airway pressure treatment modalities, Enhanced Expiratory Rebreathing Space (EERS).