CIMIT Program: Cardiovascular Disease

Cardiovascular Disease

REDUCING DEATHS AND DISABILITY FROM HEART DISEASE AND
STROKES THROUGH IMPROVED DIAGNOSIS

The leading cause of death and disability in the developed world, Cardiovascular Disease affects millions of people of all ages and frequently requires painful and invasive treatments. Most advances in treating heart disease have focused on technological innovations to treat cardiovascular disease symptoms, rather than on improving methods of detection and diagnosis.

Heart disease costs the United States billions of dollars every year, yet much of the biology is still not understood. By continually evaluating the complex set of conditions cardiac patients experience, CIMIT investigators seek novel approaches to diagnosis and therapy.

CIMIT’s Cardiovascular Disease Program is working to develop novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke.

Projects
Publications
Forum/Events

FY 2011 - 2008 Cardiovascular Disease Projects
YEAR	PRINCIPAL INVESTIGATOR	INSTITUTION	PROJECT TITLE
2011	Pedro del Nido	Children's Hospital Boston	Catheter-based adaptable device for closure of intracardiac defects in children
2010 - 2009	Robert A. Levine, MD	Massachusetts General Hospital	Operating on the Heart from Within - A Minimally Invasive Approach to Treat Mitral Valve Disease
2009	Judy Hung, MD, PhD	Massachusetts General Hospital	Polymer Injection for Treatment of Ischemic Mitral Regurgitation
2009	Guillermo Tearney MD, PhD	Massachusetts General Hospital	Integrated OFDI-Fluorescence Catheter for Imaging of Atherosclerosis
2008	Richard L. Verrier, MD	Beth Israel Deaconess Medical Center	Develoment and Clinical Database Testing of Automated ECG Heterogeneity Analyzer for Real-Time Assessment of Risk for Lethal Arrhythmia
» View all CIMIT-Funded Projects. Contact Haleh Armian, CIMIT Senior Manager, Business Development for more information regarding Commercialization Opportunities.

Recent Publications by CIMIT Investigators
INVESTIGATOR/AUTHOR	PUBLICATION	ARTICLE	DATE
Chia S, Christopher Raffel O, Takano M, Tearney GJ, Bouma BE, Jang IK.	Coron Artery Dis 18(6):423-7	In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome.	2007
Hung, J., Chaput, M., Guerrero, J. L., Handschumacher, M. D., Papakostas, L., Sullivan, S., Solis, J., Levine, R. A.	Circulation 11; 116(11 Suppl): I259-63	Persistent Reduction of Ischemic Mitral Regurgitation by Papillary Muscle Repositioning: Structural Stabilization of the Papillary Muscle-Ventricular Wall Complex	2007
Nadkarni SK, Pierce MC, Park BH, de Boer JF, Whittaker P, Bouma BE, Bressner JE, Halpern E, Houser SL, Tearney GJ	J Am Coll Cardiol. 49(13):1474-81, 2007. Opt Lett. 32(11):1560-2, 2007.	Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography.	2007
Raffel OC, Tearney GJ, Gauthier DD, Halpern EF, Bouma BE, Jang IK	Arterioscler Thromb Vasc Biol. (8):1820-7	Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography.	2007
Soltesz, E. G., Laurence, R. G., De Grand, A. M., Cohn, L. H., Mihaljevic, T., Frangioni, J. V.	Heart Surg Forum 10(5):E381-6	Image Guided Quantification of Cardioplegia Delivery During Cardiac Surgery	2007
Stone, P. H., Coskun, A. U., Kinlay, S., Popma, J. J., Sonka, M., Wahle, A., Yeghiazarians, Y., Maynard, C., Kuntz, R. E., Feldman, C. L.	Eur Heart J 28(6): 705-10	Regions of Low Endothelial Shear Stress are the Sites Where Coronary Plaque Progresses and Vascular Remodeling Occurs in Humans: an In Vivo Serial Study	2007
Yelin R, Yelin D, Oh WY, Yun SH, Boudoux C, Vakoc BJ, Bouma BE, Tearney GJ.	J Biomed Opt. 12(6):064021	Multimodality optical imaging of embryonic heart microstructure.	2007

Cardiovascular Disease at the CIMIT Forum and Past Events
EVENT	DATE	SPEAKERS	DETAIL
CIMIT Cardiovascular Conference 2008 HIGH-RISK PLAQUES: Detection and Management	May 3-4, 2008	This course will cover evolving concepts and novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke. Traditional diagnostic methods have proven invaluable for the management of atherosclerotic disease. Despite this, atherosclerotic diseases remain the leading killer of Americans. A major reason for this may lie in our limited ability to identify patients at highest risk for developing myocardial infarction and stroke. An enhanced understanding of methods and therapies to detect and treat such vulnerable patients will be offered through this course.
Faculty: Thomas J. Brady, MD; CIMIT, MGH, HMS; Aloke Finn, MD; Emory; Pallav Garg MBBS, FRACP, MSc; BWH; Marie Denise Gerhard-Herman, MD; BWH; Udo Hoffmann, MD; HMS, MGH; Farouc Jaffer, MD, PhD; HMS, MGH; Peter Libby, MD; HMS, BWH; Mohammad Madjid, MD; Texas Heart Institute; James Muller, MD; Founder, CEO, President and Chief Medical Officer, InfraRedx; Christopher O’Donnell, MD, MPh; HMS, MGH; Jorge Plutzky, MD; HMS, BWH; Paul Ridker, MD; HMS, BWH; Ernst J. Schaefer, MD; Tufts University; Peter H. Stone, MD; HMS, BWH; Ahmed A. Tawakol, MD; CIMIT, MGH; Guillermo Tearney, MD, PhD; CIMIT, MGH; Geoff Vince, PhD; VP of Clinical and Scientific Affairs, Volcano Corporation; Renu Virmani, MD; President and Medical Director, CVPath, Institute, Inc.
Forum: Cardiac Device Development	Feb. 5, 2008	Stephen N. Oesterle, MD: Senior Vice President, Medicine & Technology, Medtronic, Inc. Donald S. Baim, MD: Executive Vice President, Chief Medical and Scientific Officer, Boston Scientific	• Convergence in Health Care Technology: Devices, Biologics, Pharma, IT, Communications and Imaging • Challenges in Cardiac Device Development
Forum: New Directions in Coronary Care	Dec. 4, 2007	Ahmed Tawakol, MD; MGH Sahil Parikh, MD; BWH James Muller, MD; CEO, InfraReDx, Inc.	Advances in Intracoronary Diagnostics and Therapeutics • Drug Eluting Stents: Lessons in Biocompatibility • Advances in Intracoronary Diagnostic Methods as a Means of Matching Type of Therapy with Type of Plaque
Forum:	Sep. 25, 2007	Antonis Armoundas, PhD; HMS, MIT, MGH Richard L. Verrier, PhD, FACC, HMS, BIDMC, Harvard Institutes of Medicine	• Repolarization Alternans: From the Patient to the Bench and Back to the Patient • Dynamic Tracking of ECH Heterogeneity to Estimate Risk of Life-Threatening Arrythmias
Forum: Cardiac Imaging and Electrode Placement Modeling	Sep. 11, 2007	Patrick O’Gara, MD; BWH Matthew Jolley, MD; CHB Jeroen Stinstra, PhD; SCI Institute Utah	• Application of Cardiac Non-Invasive Imaging in Clinical Decision Making • Modeling of Optimal ICD Electrode Placement in Children and Adults
Forum: Mitral Valve Care	Jun. 5, 2007	Judy Hung, MD; MGH, HMS Michael Davidson, MD; BWH	• Mechanism of Mitral Regurgitation: Insight from 3D Echo Toward Improving Repair • From the Scalpel to the Catheter: Percutaneous Approaches to Mitral Valve Repair

Program News
ARTICLE TITLE	PUBLICATION	DATE
Made-for-the-military Products Put Brakes on Bleeding	CNN.com	March 2, 2007
More in Massachusetts Get Drug for Stroke	Boston Globe	October 20, 2006

Video: CIMIT Life-Saving Innovation in Early Stage of Trauma.

Program Leaders

Thomas Brady, MD
617-726-8313

CIMIT RESPONSIBILITIES
Co-Program Leader,
Cardiovascular DIsease

Ahmed Tawakol, MD

CIMIT RESPONSIBILITIES
Co-Program Leader,
Cardiovascular DIsease

CIMIT Community

Program Sponsor

Boston Scientific